Chrome version: 71.0.3578.127
OS: Chrome

Repro steps:
1. Open old windowed app with fixed-pixel size.
2. Maximize window, which correctly stretches the content
3. Click on things.

Expected: Registered clicks
Actual: No clicks detected

The program I'm running is a 20 year old game (Everquest) under wine, and it assumes a specific pixel density. The game looks fine when scaled up via maximize, but no longer gets mouse clicks.

When the window is scaled up in size with everything else via ctrl-shift-plus, clicks work as expected.