I'm seeing this issue as well with Chrome keyboard shortcuts on the beta channel (72.0.3626.17 (Official Build) beta (64-bit)). The previous released build on the beta channel was fine.

If I reset focus (e.g., mouse click in web content area or on tabs), then Chrome keyboard shortcuts (e.g., Ctrl + T) start working again.

FWIW, this affects all keyboard input to Chrome, not just hotkeys, e.g., if I'm composing mail in Gmail, text I type in the compose window doesn't register.

Unable to reproduce the issue on chrome reported version# 73.0.3641.0 using Windows-10 with steps mentioned below:
1) Launched chrome reported version and changed focus to Non-Chrome app
2) Used Alt+Tab to switch back to chrome, used shortcut keys(Ctrl+ T, W, N, Alt+Space, etc..), able to see operations performed successfully

@Reporter: Please find above mentioned information and attached screencast for your reference and let us know if we missed anything in reproducing the issue. Provide your feedback on it which help in further triaging it in better way.

Thanks!

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New improved repro steps:

1. Go to a web page (not the new tab page), e.g., http://www.google.com.
2. Minimize the Chrome window by clicking the icon in upper right.
3. Go back to the window with alt-tab.

Expected and actual behavior is as above.

Thanks,
Dan

Thank you for providing more feedback. Adding the requester to the cc list.

For more details visit https://www.chromium.org/issue-tracking/autotriage - Your friendly Sheriffbot

I played around with this some more.  I suspect the repro steps still won't work for you.  What I see, though I don't understand it, is:

Behavior is reproducible with my normal profile.
Behavior is reproducible in incognito mode.
Behavior is reproducible in guest mode.
Behavior is NOT reproducible if I rename my profile directory so Chrome has to create a new one.

Let me know if this suggests anything else to look at.  If not I'll just delete my profile, which should fix the problem for me.

Unable to reproduce the issue on chrome reported version# 73.0.3641.0 using Windows-10 with steps mentioned below in comment# 5
1) Launched chrome version, navigated to URL: www.google.com
2) Minimized the browser by clicking icon on top right corner
3) Now pressed "Alt+Tab", able to see focus on chrome window
Observations: Checked the shortcut keys(Ctrl+N, Ctrl+t, Ctrl+w, Alt+Space), observed all the shortcut keys working as excepted.

@Reporter: Please find the attached screencast for your reference. Try to test this issue by creating new person with no apps and extensions in it (or) on latest chrome# 73.0.3645.0 and let us know if the issue still persists. You can download latest chrome# 73.0.3645.0 from URL: https://www.chromium.org/getting-involved/dev-channel

Thanks!

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See my Comment #7.  I think that addresses your question about creating a new user.

Thank you for providing more feedback. Adding the requester to the cc list.

For more details visit https://www.chromium.org/issue-tracking/autotriage - Your friendly Sheriffbot

This has stopped happening as mysteriously as it started.  Feel free to close.

Thanks,
Dan

As per comment# 11 from the reporter closing the issue and marking it as Won't fix.
Note: Feel free to raise a new one if the issue is seen again.

Thanks!