Thanks for the report.
- Is this Outlook's desktop app, or the Outlook website?
- Does this happen with any link opened via Outlook?  
- Are inputs also unresponsive when the site is opened manually using the omnibox?
- If this only happens for a specific site, is it possible to share the link publicly, to help us reproduce?

1.it is outlook website
2.I don not know wheatear it will happen with any link, but i can give you a link to reproduce the issue.
3.This problem will not happen by using the omnibox.
4.the link to reproduce the issue: https://www.youtube.com/

Thank you for providing more feedback. Adding the requester to the cc list.

For more details visit https://www.chromium.org/issue-tracking/autotriage - Your friendly Sheriffbot

you can reproduce the problem link this.

1.you need create a folder and include a simple html file like the attachment.

2.Map html file to the local port by using Live server or other tools.

3.Send the file link(maybe like 'http://127.0.0.1:5500/Html.html') to a outlook  mailbox use Email.

4.click the link with the left mouse button in outlook.

Deleted: Html.html 247 bytes

Html.html 247 bytes View Download

Thanks for the feedback...

As per comment #5, Tried to reproduce the issue on reported chrome 70.0.3538.77 using windows 10. Attaching screencast for reference.
Steps:
-----
1. Launched chrome 
2. Downloaded given html file and kept it on one folder 
3. ran a local server and sent a link to outlook 
4. Opened outlook and clicked on link 
As we are able to click on button (As per screencast)

@Reporter: Could you please check the attached screen cast and please let us know if anything missed from our end and retry this issue with fresh profile without any extensions & apps or reset all the flags and let us know if issue still persists.

Thanks.!

Deleted: 901265.mp4 2.7 MB

	901265.mp4 2.7 MB View Download

Original reporter (harold.ligc@),

Can you please try the issue with fresh profile and let us know if it persists? (We cannot reproduce it.)