Not limited to ChromeOS. Also happens to me with dev channel 69.0.3497.12 on Windows 7.

Devtools console shows this error:

  Unchecked runtime.lastError: chrome.management.uninstall requires a user gesture.

Can't reproduce in chromium snapshots though...

I can "fix" the bug by adding "--disable-features=NativeCrxBindings" to Chrome's command line.
I still can't reproduce in Chromium snapshots even "--enable-features=NativeCrxBindings"

Thanks. The `--disable-features` parameter works around the bug for me.

 Issue 871016  has been merged into this issue.

Able to reproduce the issue on Chrome 69.0.3497.29/10895.16.0-Jerry, Wolf, Kevin.  
Steps to reproduce :
1. update Chromeos build from 69.0.3497.26/10895.13.0 to 69.0.3497.29/10895.16.0 (jerry)
2. open chrome://extensions
3. click "Remove" button
Nothing happens after clicking "Remove" button

======
After "powerwash" the system, the "Remove" button works fine. 

Unable to reproduce the issue if the chromeos is installed with the USB/10895.16.0_jerry recovery image. 

Able to reproduce the issue on 69.0.3497.29/10895.16.0-Big. 
The "Remove" button works fine With the "--disable-features=NativeCrxBindings" flags,comment#3.  

Unable to reproduce the issue on reported chrome version 69.0.3494.0 and latest Dev 70.0.3510.2 using Windows 10. Attaching screen-cast for reference.
Steps
---------
1. Launched reported chrome 
2. Enable extensions as per screen-cast  
3. Navigated >> More Tools >> Extensions in Chrome
4. Clicked on remove
As we are observed that Extensions are removed successfully 

@Reporter:  Please find the attached screen-cast and let us know if we have missed anything in the process.

Thanks.!

Deleted: 866576.mp4 3.7 MB

	866576.mp4 3.7 MB View Download

Devlin -> for *potential* native bindings regression (see comment #9)

Thank you for the report!

It looks like this is dependent on *two* different features: NativeCrxBindings and User Action V2.  I can reproduce by
- Enabling chrome://flags/#user-activation-v2
- Appending --enable-features=NativeCrxBindings
- Going to the chrome://extensions page and trying to uninstall an extension

mustaq@, it looks like you updated the code for the old extensions code path in https://chromium-review.googlesource.com/c/chromium/src/+/747401, but not for the new.  Can you take a look?

Looks like the core problem for this bug is  Issue 778769 ?  If this is not the case, please point me to the "the new code path" noted in #c12 above.

Ah, yep, that's the one.  Same root cause.

Removing the regression label: it was exposed through a Canary/Dev finch trial.