Unable to reproduce this issue on reported version 66.0.3359.181 and on latest stable 67.0.3396.79 using Windows 10 with steps mentioned above. i.e; Cursor changes from default to move cursor on clicking,even when devtools is opened. Attaching screencast for reference.

@Reporter: Please check the video and let us know if we miss anything. Please upgrade chrome to latest stable and let us know the behavior. If issue is still reproducible check the issue by disabling all apps/extensions and by resetting all flags to default in chrome://flags.

Thanks!

Deleted: 850404.mp4 2.4 MB

	850404.mp4 2.4 MB View Download

I've noticed you're comment above and re-checked this issue again.
Indeed, if I keep Dev Tools docked to by browser, as it can be seen in your video, it doesn't reproduce.

So I hope below steps will help identifying the issue:
1. Open Dev Tools, undock instance in separate window
2. Close Dev Tools and reopen it (it should now open in a separate window by default)
3. Hold mouse down inside the red background rectangle in above fiddle

Expected:
The cursor should changed imediately

Actual:
The cursor changes to "move" after mouse up, and imediately changes to default after mouse move

Best regards!

Thank you for providing more feedback. Adding the requester to the cc list.

For more details visit https://www.chromium.org/issue-tracking/autotriage - Your friendly Sheriffbot

I noticed another thing, if I leave the Dev Tools opened and undocked, than navigate to another url and press back to the page with the change-cursor script, Chrome behaves as expected.

Joel, do we lack some invalidation on class list update?

We don't invalidate when the psuedoclass changes due to hover/active