For a page which uses mutation observer like the following code
var observer = new MutationObserver(
(mutations) => {console.log('Mutation observer ran.');});
observer.observe(document.body, {childList: true});
If the script is disabled from Dev tools>Settings, the following call should not trigger invoking mutation observer .
document.body.appendChild(document.createTextNode('ha'));
Comment 1 by pfeldman@chromium.org
, May 31 2018