Chrome Version: 65.0.3322.0

Most keyboard shortcuts are disabled when only the wallpaper is in the foreground (ie, when no windows are open and un-minimized). This includes the Launcher key; shell shortcuts like Alt+Shift+S (system tray), Ctrl+Alt+? (keyboard shortcut overlay), or Ctrl+Alt+. (multi-profile switcher); and launching shelf items like Alt+1.

The only shortcuts that seem to work are Alt+Tab and the Assistant key. Hotkeys like volume, brightness, and the window switcher also work.

If a window or some system UI is open, shortcuts work again.

Happens for both accounts in multi-profile mode.

1. Close or minimize all windows.
2. Press the Launcher key or a keyboard shortcut like Alt+Shift+S, Alt+1, Ctrl+Alt+?.

Nothing happens.

3. Show shell UI such as right-clicking the desktop, opening the system tray, or opening the notifications tray.
4. Press a keyboard shortcut.

Shortcuts work.