Might be a duplicate of  issue 679461 

>Do you have Tampermonkey extension? It adds a browser-scope Ctrl-Shift-E to enable/disable the extension, which is also active in incognito mode. The shortcut keys may be disabled or customized on chrome://extensions page in browser settings.

Also, the repro case code compares event.key to "e" but actually "E" is sent because Shift is pressed. See the specs [1].

Here's the updated code: https://jsfiddle.net/ep63bavn/1/

However, I can't repro the bug unless I install Tampermonkey or other extension that adds Ctrl-Shift-E. The shortcut keys may be disabled or customized on chrome://extensions page in browser settings.

The underlying problem is that Chrome doesn't provide a user-friendly way to see and customize those hotkeys. Currently the feature is deeply buried [2] and hardly undiscoverable, there's also no indication of hotkeys being used by an extension in the list of installed extensions on chrome://extensions page, there's no "customize shortcuts" link in the extension toolbar icon rightclick menu (it might have been shown at least in case the extension has a hotkey).

  [1]: https://w3c.github.io/uievents/#keys-keyvalues
  [2]: http://www.howtogeek.com/127162/how-to-create-custom-keyboard-shortcuts-for-browser-actions-and-extensions-in-google-chrome/

^ typo, should read "hardly discoverable"

Tested in chrome # 56.0.2924.87 and Canary #58.0.3013.0 on win 10.0 and 7 and not getting the alert with pass.Please find the screen shots for your reference.
Steps followed:
1.Added Tampermonkey extensions and enable the shortcut key in chrome://extensions page.
2.Navigate to above URL in comment#3
3.press Ctrl+Shift+E

@mogrossm / woxxom :

Could you please let me know if i have missed anything and if possible, provide us with a sample steps of the issue which would help us to triage the issue further.

Note: Same behavior observed in older version(M30 - M58)

Thanks in Advance.

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Thanks for the investigation! We're all set now :)

Thanks for the update.
Can we close this issue as per comment #6?

Thanks,

Yes, thank you very much!

Thank you for providing more feedback. Adding requester "rbasuvula@chromium.org" for another review and adding "Needs-Review" label for tracking.

For more details visit https://www.chromium.org/issue-tracking/autotriage - Your friendly Sheriffbot

As per comment #8 , marking it as won't fix as this issue no longer exists. Please feel free to raise a new issue this if you face this again.

Thanks!