If you set a breakpoint in DevTools in an extension before any chrome.* objects are accessed and then type 'chrome' into the console, you get

(BLESSED_EXTENSION context for eemcgdkfndhakfknompkggombfjjjeno) Lazy require of app.binding did not set the binding field

The uncaught native gets disabled and the whole page is borked.

The easiest repro is to set a breakpoint in the Chrome Bookmark Manager at main.js:8.

Assigning to rdevlin.cronin@ for triage.