UserAgent: Mozilla/5.0 (Macintosh; Intel Mac OS X 10_11_3) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/51.0.2704.103 Safari/537.36

Example URL:
https://s3.amazonaws.com/truffle-repro/foo.mp4

Steps to reproduce the problem:
0. Go to chrome://flags to double check if video decode acceleration is enabled (default for my combination of chrome/osx)
1. Load URL directly, notice video doesn't play
2. Load chrome://media-internals - notice and error for this asset

It works if I follow these steps

1. Go to chrome://flags
2. Disable hardware accelerated decode
3. Load the video
4. It works

What is the expected behavior?
The video should play regardless of video acceleration setting.

The video plays correctly under Firefox 45.0.2, VLC and Quicktime (OSX 10.11).

What went wrong?
The video never started playing under hardware acceleration, with the HTML5 video element throwing a MEDIA_ERROR code 3.

Did this work before? N/A 

Is it a problem with Flash or HTML5? HTML5

Does this work in other browsers? Yes 

Chrome version: 51.0.2704.103  Channel: n/a
OS Version: OS X 10.11.3
Flash Version: Shockwave Flash 22.0 r0

Seems acceleration related, but I'm too ignorant about chrome to be able to say more.

Here's the ffprobe output for the video:

ffprobe version 3.0.2 Copyright (c) 2007-2016 the FFmpeg developers
  built with Apple LLVM version 7.0.2 (clang-700.1.81)
  configuration: --prefix=/usr/local/Cellar/ffmpeg/3.0.2 --enable-shared --enable-pthreads --enable-gpl --enable-version3 --enable-hardcoded-tables --enable-avresample --cc=clang --host-cflags= --host-ldflags= --enable-opencl --enable-libx264 --enable-libmp3lame --enable-libxvid --enable-libtheora --enable-libvorbis --enable-libvpx --enable-libass --enable-openssl --enable-libx265 --enable-nonfree --enable-vda
  libavutil      55. 17.103 / 55. 17.103
  libavcodec     57. 24.102 / 57. 24.102
  libavformat    57. 25.100 / 57. 25.100
  libavdevice    57.  0.101 / 57.  0.101
  libavfilter     6. 31.100 /  6. 31.100
  libavresample   3.  0.  0 /  3.  0.  0
  libswscale      4.  0.100 /  4.  0.100
  libswresample   2.  0.101 /  2.  0.101
  libpostproc    54.  0.100 / 54.  0.100
Input #0, mov,mp4,m4a,3gp,3g2,mj2, from 'foo.mp4':
  Metadata:
    major_brand     : isom
    minor_version   : 512
    compatible_brands: isomiso2avc1mp41
    encoder         : Lavf57.25.100
  Duration: 00:04:38.04, start: 0.000000, bitrate: 10028 kb/s
    Stream #0:0(eng): Video: h264 (High) (avc1 / 0x31637661), yuv420p(tv, bt709), 1080x1920 [SAR 1:1 DAR 9:16], 10026 kb/s, 25 fps, 25 tbr, 25k tbn, 50 tbc (default)
    Metadata:
      handler_name    : VideoHandler

Let me know anything I can do to help, and I apologize if this is a duplicate - only references I found to hardware accelerated decoding issues were related to VP9 / youtube.