This does not appear to be Settings-specific, so moving to the Plugins label.

The same issue starting 54.0.2810.2.
No flags are used. No content blocking extensions are installed.

Google Chrome	54.0.2810.2 (Official Build) dev-m (64-bit)
Revision	84cc4cdf21633b6209f2561e78fea87d40e84329-refs/branch-heads/2810@{#5}
OS	Windows 
JavaScript	V8 5.4.278
Flash	22.0.0.209
User Agent	Mozilla/5.0 (Windows NT 10.0; Win64; x64) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/54.0.2810.2 Safari/537.36
Command Line	"C:\Program Files (x86)\Google\Chrome\Application\chrome.exe" --flag-switches-begin --flag-switches-end
Executable Path	C:\Program Files (x86)\Google\Chrome\Application\chrome.exe
Profile Path	C:\Users\User\AppData\Local\Google\Chrome\User Data\Default

jawaadt@: Could you please confirm any such URL where the issue is seen. Please check the same in incognito mode and let us know if the issue is seen there as well.

The issue is actually no longer happening as of a week ago.  I will continue to monitor and close the ticket for now.

Thanks for the update, closing the ticket as per C#4. Feel free to file a new issue if you encounter such issues.