Bisection indicates that this change introduced the issue:
https://chromium.googlesource.com/chromium/src/+log/6bebadddb399ad1c1f91592efed410040617e708..5840ac85a7c912d9ddb764007b6a9ec65a26ad22

Version: 
PASS: Mac 10.11 / Chrome 51.0.2687.0(Rev. no. 382335) / 22.0.0.199
FAIL: Mac 10.11 / Chrome 51.0.2687.0(Rev. no. 382346) / 22.0.0.199
FAIL: Win 10 / Chrome 51.0.2704.106 / 22.0.0.204

What steps will reproduce the problem?

1) Go to https://apps.facebook.com/angrybirds/?fb_source=search&ref=br_tf
2) Login and let the game load
3) Select Play option and then tournament no. e.g. 1
4) Click on full screen button
5) Zoom-in and Zoom-out using mouse scroll wheel 

What is the expected output?
Screen should not flicker

What do you see instead?
Screen flickers on Zoom-in while in full screen mode. Works fine in normal mode

NOTE: Issue is more clearly noticeable with wireless mouse in Mac

Please use labels and text to provide additional information.