Could you also provide the error message you are seeing on www.twitter.com?
(copy the text from developer console).

At least www.twitter.com icons are working for me, it's hard to investigate
without reliable reproduction.

The font used in twitter seems to be called "rosetta" in CSS and its
URL is https://abs.twimg.com/a/1457833503/font/rosetta-icons-Regular.woff
(for me, may differ in other account).

Most probably your browser failed to load the font file for both twitter
and upwork.

Not just twitter or upwork, many sites are experiencing the same problem. For ex: elementary.io and even the chrome's new download manager page is also not CSS applied. Included screenshots for the same.

Here is the text from developer console and also attached screenshot of the same on twitter site:

Failed to decode downloaded font: https://abs.twimg.com/a/1457833503/font/rosetta-icons-Regular.woff
(index):1 Failed to decode downloaded font: https://abs.twimg.com/a/1457833503/font/rosetta-icons-Regular.ttf
init.2d14663….js:363 POST https://twitter.com/i/videoads/v2/prerolls.json net::ERR_BLOCKED_BY_CLIENTsend @ init.2d14663….js:363n.extend.ajax @ init.2d14663….js:351JSONRequest @ init.2d14663….js:642post @ init.2d14663….js:642fetchAds @ boot.0d9b154….js:393fetchAdsAndCache @ boot.0d9b154….js:393initialAdFetch @ boot.0d9b154….js:393(anonymous function) @ boot.0d9b154….js:393(anonymous function) @ init.2d14663….js:495(anonymous function) @ init.2d14663….js:495(anonymous function) @ init.2d14663….js:499n.extend.each @ init.2d14663….js:69n.fn.n.each @ init.2d14663….js:61j @ init.2d14663….js:499module.exports @ boot.0d9b154….js:778module.exports @ timeline.52e11aa….js:428(anonymous function) @ init.2d14663….js:1192e @ init.2d14663….js:1192b @ init.2d14663….js:1196z.complete @ init.2d14663….js:434b @ init.2d14663….js:445z.complete @ init.2d14663….js:434(anonymous function) @ init.2d14663….js:439z.complete @ init.2d14663….js:434D.complete @ init.2d14663….js:445(anonymous function) @ init.2d14663….js:444l @ init.2d14663….js:455z.complete @ init.2d14663….js:434b @ init.2d14663….js:445z.complete @ init.2d14663….js:434(anonymous function) @ init.2d14663….js:439z.complete @ init.2d14663….js:434D.complete @ init.2d14663….js:445(anonymous function) @ init.2d14663….js:444l @ init.2d14663….js:455z.complete @ init.2d14663….js:434b @ init.2d14663….js:445z.complete @ init.2d14663….js:434(anonymous function) @ init.2d14663….js:439z.complete @ init.2d14663….js:434D.complete @ init.2d14663….js:445(anonymous function) @ init.2d14663….js:444l @ init.2d14663….js:455z.complete @ init.2d14663….js:434b @ init.2d14663….js:445z.complete @ init.2d14663….js:434(anonymous function) @ init.2d14663….js:439z.complete @ init.2d14663….js:434D.complete @ init.2d14663….js:445(anonymous function) @ init.2d14663….js:444l @ init.2d14663….js:455z.complete @ init.2d14663….js:434b @ init.2d14663….js:445z.complete @ init.2d14663….js:434(anonymous function) @ init.2d14663….js:439z.complete @ init.2d14663….js:434D.complete @ init.2d14663….js:445(anonymous function) @ init.2d14663….js:444l @ init.2d14663….js:455z.complete @ init.2d14663….js:434b @ init.2d14663….js:445z.complete @ init.2d14663….js:434(anonymous function) @ init.2d14663….js:439z.complete @ init.2d14663….js:434D.complete @ init.2d14663….js:445(anonymous function) @ init.2d14663….js:444l @ init.2d14663….js:455z.complete @ init.2d14663….js:434b @ init.2d14663….js:445z.complete @ init.2d14663….js:434(anonymous function) @ init.2d14663….js:439z.complete @ init.2d14663….js:434D.complete @ init.2d14663….js:445(anonymous function) @ init.2d14663….js:444l @ init.2d14663….js:455z.complete @ init.2d14663….js:434b @ init.2d14663….js:445z.complete @ init.2d14663….js:434(anonymous function) @ init.2d14663….js:439z.then @ init.2d14663….js:431B.start @ init.2d14663….js:439(anonymous function) @ init.2d14663….js:440z.complete @ init.2d14663….js:434A.loaded @ init.2d14663….js:439C.loaded @ init.2d14663….js:443b.onreadystatechange.b.onload @ init.2d14663….js:437
www.google.com/ads/ga-audiences?v=1&aip=1&t=sr&_r=4&tid=UA-30775-6&cid=742928670.1457596374&jid=769347888&_v=j41&z=1333176040:1 GET https://www.google.com/ads/ga-audiences?v=1&aip=1&t=sr&_r=4&tid=UA-30775-6&cid=742928670.1457596374&jid=769347888&_v=j41&z=1333176040 net::ERR_BLOCKED_BY_CLIENT
692634046338244608:1 Failed to decode downloaded font: https://amp.twimg.com/amplify-web-player/prod/styles/font/rosetta-icons-Regular.woff
692634046338244608:1 Failed to decode downloaded font: https://amp.twimg.com/amplify-web-player/prod/styles/font/rosetta-icons-Regular.ttf

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Thank you for providing more feedback. Assigning to requester "ksakamoto@chromium.org" for another review.

For more details visit https://sites.google.com/a/chromium.org/dev/issue-tracking/autotriage - Your friendly Sheriffbot

AFAK, enabling the Windows Firewall Service will solve this problem. I did this to help some guys out. You may check the status of Windows Firewall Service on your machine.
See links below:
http://superuser.com/questions/957907/unable-to-install-fonts-on-windows-10
https://www.reddit.com/r/Windows10/comments/3fb8ya/cannot_install_any_fonts_at_all

Just find out that this issue has been fixed.
https://bugs.chromium.org/p/chromium/issues/detail?id=586291

I am using windows firewall and its not disabled. Unfortunately none of the links that you shared to fix the problem were able to help me in this regard.

This seems Webpage rendering engine level problem. propagated to opera browser too! :) Anyway, Bug ID: 586291 says its fixed and expected to be shipped in Chrome 50 release. Any idea when is the next update release?

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Hi pavan.gayakwad@,

Have you disabled DirectWrite? chrome://flags/#disable-direct-write
If you flip this flag, does the problem disappear?

you nailed it! After Enabling DirectWrite flag, everything seems perfect!! so there sits the bug!! :)

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(cc:ing DirectWrite experts)

Thanks for the info. Just to confirm...
The DirectWrite flag is enabled by default. You disabled it, correct?

Yes, I intentionally disabled it, it was enabled by default.

This was mitigation related or something (maybe?)

Sorry Scott.  Font-related mitigation on Win10 only landed in M50.  (For ref: https://bugs.chromium.org/p/chromium/issues/detail?id=504006)

So it means the fix can be seen only in Chrome 50 release? Is the bug at DirectWrite level fixed?

Cleaning up "Needs-Review" label as we are not using this label for triage anymore. Ref bug for this cleanup 684919