Tested the issue on Windows 7 using 49.0.2623.75 with below steps:

1.Opened new tab.
2.Opened link 'https://amplusnet.shiftplanning.com/ical/0cf141aaf857fe9651df5c1974a85290.ics?1457306767271', .ics file downloaded.
3.After download complete, clicked on it to open in new tab.
4.File opened in notepad.
5.Opened .ics file notepad as .html in chrome.

Please find attached screencast and update if anything missed here in triaging the issue.

robexms2005@Could you please provide actual and expected behavior screencast for better understanding the issue to triage it further.

Deleted: 592273.mp4 2.6 MB

592273.mp4 2.6 MB Download

Hello,

First of all sorry for my bad explanation (English is not my native language).
So in simple way to say:
The new tab you use to download the file will became unusable even if I move the cursor over the thumbs and react, if I click on them will not open the page.
Video attached. 

Deleted: 2016-03-07_160552277.mp4 8.3 MB

2016-03-07_160552277.mp4 8.3 MB Download

Thanks for reporting!
I can reproduce this problem on Mac Stable M48, but not on Mac Canary M50 or Linux Beta M49. Interesting.

Any update on this case?

I can't reproduce this anymore on the latest Chrome Stable on Win7
49.0.2623.87 (Official Build) m (32-bit)

Could you try again if the problem still exists?

The bug is still on.

Thanks for checking again!
I can now reproduce it again too.

Notes to self:
The thumbnails sometimes still work after a download - seems that MostLikely thumbs still work, but TopSites ones don't?
The fakebox always seems to break.
Also happens on the local NTP.

Theory: The download is kinda-sorta a navigation. This causes the NTP to lose its "Instant" status, i.e. it loses access to the embeddedSearch APIs. That would cause the fakebox and TopSites tiles to stop working.

The following revision refers to this bug:
  https://chromium.googlesource.com/chromium/src.git/+/cb3d859ad53f667a8cca5cb5d18ed09b13c51ef8

commit cb3d859ad53f667a8cca5cb5d18ed09b13c51ef8
Author: Marc Treib <treib@chromium.org>
Date: Mon Dec 04 16:25:08 2017

search::IsInstantNTP: Prefer committed over visible URL

The visible URL doesn't always correspond to the actual page that's
loaded. For example, if the user types in a URL that ends up being a
download, then the visible URL corresponds to the download, but the NTP
is still there and should remain functional.

Bug:  592273 , 624410
Change-Id: Ib2e0a7df8658e55030ee5e67959a0ebc486e495d
Reviewed-on: https://chromium-review.googlesource.com/800931
Reviewed-by: Chris Pickel <sfiera@chromium.org>
Commit-Queue: Marc Treib <treib@chromium.org>
Cr-Commit-Position: refs/heads/master@{#521359}
[modify] https://crrev.com/cb3d859ad53f667a8cca5cb5d18ed09b13c51ef8/chrome/browser/search/search.cc
[modify] https://crrev.com/cb3d859ad53f667a8cca5cb5d18ed09b13c51ef8/chrome/browser/search/search.h
[modify] https://crrev.com/cb3d859ad53f667a8cca5cb5d18ed09b13c51ef8/chrome/browser/search/search_unittest.cc
[modify] https://crrev.com/cb3d859ad53f667a8cca5cb5d18ed09b13c51ef8/chrome/browser/ui/search/local_ntp_browsertest.cc
[modify] https://crrev.com/cb3d859ad53f667a8cca5cb5d18ed09b13c51ef8/chrome/browser/ui/search/search_ipc_router_policy_unittest.cc

Alright, this should fix the issue. Let's see if I broke anything else in the process...

The following revision refers to this bug:
  https://chromium.googlesource.com/chromium/src.git/+/99d09111f96d38651656311f16832742352f0f34

commit 99d09111f96d38651656311f16832742352f0f34
Author: Marc Treib <treib@chromium.org>
Date: Thu Dec 07 14:46:38 2017

Local NTP download test: don't leak downloaded files

Before this CL, LocalNTPTest.EmbeddedSearchAPIAfterDownload stored a
test download file into the system's actual downloads folder, and left
it there after the test ended. This CL instead sets up a temporary
folder as the download folder.

Bug:  592273 
Change-Id: I27aa103b4c69b7c6a6bba755f74ee0bcb9fe2c84
Reviewed-on: https://chromium-review.googlesource.com/814115
Reviewed-by: Chris Pickel <sfiera@chromium.org>
Commit-Queue: Marc Treib <treib@chromium.org>
Cr-Commit-Position: refs/heads/master@{#522424}
[modify] https://crrev.com/99d09111f96d38651656311f16832742352f0f34/chrome/browser/ui/search/local_ntp_browsertest.cc